[Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3].
Identifieur interne : 002D88 ( Main/Exploration ); précédent : 002D87; suivant : 002D89[Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3].
Auteurs : Iu A. Desheva ; T A Smolonogina ; M V Sergeeva ; A R Rekstin ; D. Swayne ; A I Klimov ; L G RudenkoSource :
- Zhurnal mikrobiologii, epidemiologii, i immunobiologii [ 0372-9311 ]
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (analyse), Basse température, Grippe humaine (), Humains, Muqueuse nasale (immunologie), Muqueuse nasale (virologie), Poulets, Réplication virale, Souris, Souris de lignée BALB C, Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité), Virus recombinants (génétique), Virus recombinants (immunologie), Virus recombinants (pathogénicité).
- MESH :
- analyse : Anticorps antiviraux.
- génétique : Vaccins antigrippaux, Virus de la grippe A, Virus recombinants.
- immunologie : Muqueuse nasale, Vaccins antigrippaux, Virus de la grippe A, Virus recombinants.
- pathogénicité : Virus de la grippe A, Virus recombinants.
- virologie : Muqueuse nasale.
- Animaux, Basse température, Grippe humaine, Humains, Poulets, Réplication virale, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (analysis), Chickens, Cold Temperature, Humans, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Mice, Mice, Inbred BALB C, Nasal Mucosa (immunology), Nasal Mucosa (virology), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Reassortant Viruses (pathogenicity), Virus Replication.
- MESH :
- chemical , analysis : Antibodies, Viral.
- genetics : Influenza A virus, Influenza Vaccines, Reassortant Viruses.
- immunology : Influenza A virus, Influenza Vaccines, Nasal Mucosa, Reassortant Viruses.
- pathogenicity : Influenza A virus, Reassortant Viruses.
- prevention & control : Influenza, Human.
- virology : Nasal Mucosa.
- Animals, Chickens, Cold Temperature, Humans, Mice, Mice, Inbred BALB C, Virus Replication.
Abstract
For the development of live attenuated influenza vaccine (LAIV) against influenza virus strains with pandemic potential, method of classic genetic reassortment of donor of attenuation A/Leningrad/134/17/57 (H2N2) [Len/17] with avian apathogenic influenza viruses of different subtypes was used. Strain with genome formula 6:2, which contains HA and NA genes from avian apathogenic virus A/wild duck/Netherlands/12/00 (H7N3) [N7N3-wt] and 6 other genes--from Len/17, was studied. Reassortant strain A/17/ wild duck/Netherlands/00/84 (H7N3) [Lenl7/ H7] exhibited ts- and ca- phenotype specific for cold-adapted strains. Reassortant was identical on antigenic profile to parent avian virus H7N3-wt. Like cold-adapted donor strain Len/17, Len17/H7 was attenuated for chickens, whereas wild-type parent strain was lethal in 60% of birds after its intravenous challenge. Reassortant strain Len17/H7 was attenuated during intranasal inoculation of 6 EID50 to white mice, which was confirmed by absence of its isolation from the lungs, actively reproduced on nasal mucosa and stimulated specific systemic and local antibody response.
PubMed: 19340965
Affiliations:
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Le document en format XML
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Strain with genome formula 6:2, which contains HA and NA genes from avian apathogenic virus A/wild duck/Netherlands/12/00 (H7N3) [N7N3-wt] and 6 other genes--from Len/17, was studied. Reassortant strain A/17/ wild duck/Netherlands/00/84 (H7N3) [Lenl7/ H7] exhibited ts- and ca- phenotype specific for cold-adapted strains. Reassortant was identical on antigenic profile to parent avian virus H7N3-wt. Like cold-adapted donor strain Len/17, Len17/H7 was attenuated for chickens, whereas wild-type parent strain was lethal in 60% of birds after its intravenous challenge. Reassortant strain Len17/H7 was attenuated during intranasal inoculation of 6 EID50 to white mice, which was confirmed by absence of its isolation from the lungs, actively reproduced on nasal mucosa and stimulated specific systemic and local antibody response.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Desheva, Iu A" sort="Desheva, Iu A" uniqKey="Desheva I" first="Iu A" last="Desheva">Iu A. Desheva</name><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name><name sortKey="Sergeeva, M V" sort="Sergeeva, M V" uniqKey="Sergeeva M" first="M V" last="Sergeeva">M V Sergeeva</name><name sortKey="Smolonogina, T A" sort="Smolonogina, T A" uniqKey="Smolonogina T" first="T A" last="Smolonogina">T A Smolonogina</name><name sortKey="Swayne, D" sort="Swayne, D" uniqKey="Swayne D" first="D" last="Swayne">D. Swayne</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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